Hussein Tawbi, M.D./Ph.D.
Department of Medicine
University of Pittsburgh
5117 Centre Avenue
Pittsburgh, PA 15213
The focus of my research is the elucidation of the epigenetic regulation of DNA repair pathways and their modulation to reverse chemotherapy resistance in melanoma. The scope of my research spans the design and conduct of early-phase clinical trials with the inclusion of translational research endpoints, and extends to laboratory efforts to elucidate the mechanisms underlying clinical observations using cell and molecular biology tools. In addition, I am interested in the development of mechanism-based drug combinations to treat melanoma.
Tawbi HA, Buch SC (2010). Chemotherapy resistance abrogation in metastatic melanoma. Clin Adv Hematol Oncol. 8: 259-266.
Tawbi H, Nimmagadda N (2009). Targeted therapy in melanoma. Biologics. 3: 475-484.
Tarhini AA, Kirkwood JM, Tawbi H, Gooding WE, Islam MF, Agarwala SS (2008). Safety and efficacy of arsenic trioxide for patients with advanced metastatic melanoma. Cancer 112: 1131-1138.
Tawbi HA, Kirkwood JM (2007). Management of metastatic melanoma. Semin Oncol. 34: 532-545.